Biochem/physiol Actions
Primary Targetcytidine deaminase
Reversible: yes
Cell permeable: yes
General description
A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486.r>Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.Riva, C., et al. 1992. Chemotherapy38, 358.Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.
Packaging
25 mg in Glass bottle
Packaged under inert gas
Physical form
A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H2O.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: